Regulation of apoptosis-related genes by nitric oxide in cancer

Nitric Oxide / Cyclic Nucleotide Regulation of Globin Genes in Erythropoiesis

Vladan P. Čokić1, Bojana B. Beleslin-Čokić2, Gordana Jovčić1, Raj K. Puri3 and Alan N. Schechter4 1Laboratory of Experimental Hematology, Institute for Medical Research, Belgrade, 2Clinic of Endocrinology, Diabetes and Diseases of Metabolism, School of Medicine, University Clinical Center, Belgrade, 3Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and...

Nitric oxide-mediated regulation of chemosensitivity in cancer cells.

BACKGROUND Hypoxia in tumors is associated with malignant progression, metastatic spread, and increased resistance to radiotherapy and chemotherapy. Molecular O(2) is required for the cellular production of nitric oxide (NO) by the enzyme NO synthase (NOS), and NO may block components of the adaptive response to hypoxia. Hence, we hypothesized that hypoxia increases drug resistance in tumor cel...

Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR.

The human pathogen Neisseria meningitidis is capable of growth using the denitrification of nitrite to nitrous oxide under microaerobic conditions. This process is catalyzed by two reductases: nitrite reductase (encoded by aniA) and nitric oxide (NO) reductase (encoded by norB). Here, we show that in N. meningitidis MC58 norB is regulated by nitric oxide via the product of gene NMB0437 which en...

TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis.

Nitric oxide (NO) is a potent activator of the p53 tumor suppressor protein, thereby inducing cell cycle arrest and apoptosis. However, little is known about the regulation of the two other p53-family members, p63 and p73, by nitrogen oxides. We report here an up-regulation of p73 by NO in p53-null K-562 leukemia cells. Chemical NO prodrugs or macrophage iNOS activity induced an accumulation of...

Nitric Oxide Induces Thymocyte Apoptosis